Canine valley fever question

What's the prognosis for my 3 yr old dog, who's limping due to probable bone
lesions, and a history of skin lesions(finally stopped after 4 months of
fluconazole). She's been treated with 105 mgs.daily fluconazole for a year now,
and doesn't show any signs of improvement. I've been trying to limit her
mobility, as that seems to lessen the limp slightly. She misses her morning run
down to the mailbox!

BTW, the vet has now doubled her dose of fluconazole.